Cancer Prevention Coalition Cancer Prevention Coalition  

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Fighting for a safer environment at home, in the community, and at work

Samuel S. Epstein, M.D.
Cancer Prevention Coalition

c/o University of Illinois at Chicago

School of Public Health, MC 922
2121 West Taylor Street
Chicago, IL 60612

Phone: 312-996-2297
Fax: 312-413-9898 (please include a cover sheet)


Margie Aliprandi, CPC National Director of Local Offices, has agreed to take a lead role in the development of our national and international Offices - regional or local, help coordinate their activities, and organize bimonthly conference calls between Offices and Dr. Epstein.  Discussion topics for the calls include consumer product safety, and broader aspects of the science and politics of cancer cause and prevention.

June Milich, CPC Assistant National Director

Regional Director of California & Hawaii

Local CPC offices in the U.S. and Canada

U.S. Regional Directors

International National Directors

International Local Office Directors


More information on Local Office Directors (LOD)


JOIN the CPC, or RENEW your membership.

CPC is a registered 501(c)3 non-profit organization.  Donations are tax-deductible.


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S an important factor for cancer metastasis, although it cannot be judged only from expression of integrins on the tumor cells whether the tumor cells have highly metastatic capacities. Most integrins are expressed on a wide variety of cells and most cells express several integrins (14). Integrins are heterodimers, composed of an a subunit and a î² subunit, and play an important role in the attachment of a cell to a cell and to an extracellular matrix. viagra no prescription Vla-4 is the complex of î±4 and î²1 subunits and is the receptor to fibronectin. The number of adherent cells to a vc am-1-coated well is significantly decreased by vitamin d3, which suppresses the expression of î±4 integrin mrna (15). The adhesion of renal cell carcinoma cells was also inhibited by anti-î±4 antibody (16). These facts might suggest the involvement î±4 integrin in hematogenous metastasis. The processes of migration and invasion are likely to involve specific cell surface receptors, such as receptors for the extracellular matrix molecules (17). Wdc-1 cells highly expressed î²1 integrin. It is necessary to evaluate whether high expression of the î²1 integrin makes the tumor cells metastasize to lymph nodes or not because anti-î²1 integrin monoclonal antibody inhibits the migration and invasion of tumor cells (18,19). We are now proceeding to investigate the mechanism for the metastasis of wdc-1 cells and these findings may improve the understanding of the biological features of duodenal carcinoma. Previous section next section footnotes abbreviations cea carcinoembryonic antigen ca19-9 carbohydrate antigen 19-9 afp î±-fetoprotein slx sialyl lex vla very late antigen â© 1999 foundation for promotion of cancer research previous section â  references ↵ joesting dr , beart rw , vanheerden ja , weiland lh. generic viagra prices Improving survival in adenocarcinoma of the duodenum. Am j surg 1981;141:228-31. Viagra no prescription Crossref medline web of science ↵ spira ia , ghazi a , wolff wi. Primary adenocarcinoma of the duodenum. Cancer 1976;39:1721-6. Crossref web of science ↵ williams by , schonbrunn a. Bombesin receptors in a human duodenal tumor cell line: binding properties and function. Cancer res 1994;54:818-24. Abstract / free full text ↵ yamaue h , tanimura h , tsunoda t , tani m , iwahashi m , noguchi k , et al. Chemosensitivity testing with highly purified fresh human tumor cells using the mtt colorimetrie assay. Eur j cancer 1991;27:1258-63. Crossref medline web of science yamaue h , tanimura h , noguchi k , hotta t , tani m , tsunoda t , et al. Chemosensitivity testing of fresh human gastric cancer with highly purified tumour cells using mtt assay. cheap viagra next day delivery Br j cancer 1992;66:794-9. Medline web of science ↵ tani m , tanimura h , yamaue h , mizobata s , iwahashi m , tsunoda t , et al. Generation of cd4+ cytotoxic t lymphocytes stimulated by immobilized anti-cd3 monoclonal antibody and interleukin-2 in cancer patients. Int j cancer 1995;60:802-7. Crossref medline web of science ↵ tani m , tanimura h , yamaue h , hotta t , iwahashi m , terasawa h , et al. Evaluation of mtx/5-fu sequential chemotherapy utilized mtt assay for gastrointestinal cancer. Oncol rep 1996;3:41-3. Medline ↵ seabright m. Generic viagra online A rapid banding technique for human chromosomes. viagra no prescription Lancet 1971;2:971-2. buying online viagra Medline web of science ↵ kleinerman j , yardumian k , tamaki h. Primary carcinoma of the duodenum. Ann intern med 1950;32:451. Cheap viagra for sale Crossref web of science ↵ schmit m , deschner ee , thaler ht , clements l , good ra. Gastrointestinal cancer studies in the human to nude mouse heterotransplant system. Gastroenterology 1977;72:829-37. Medline web of science ↵ riedel hd , remus aj , fitscher ba , stremmel w. Characterization and partial purification of a ferrireductase from human duodenal microvillus membranes. Biochem j 1995;309:745-8. Medline ↵ shimizu n , yamashiro h , murakami a , hamazoe r , maeta m. Diagnostic accuracy of combination of assays for immunosuppressive acidic protein and carcinoembryonic antigen in detection of recurrence of gastric cancer. Eur j cancer 1991;27:190-3. Crossref medline web of science ↵ santeusanio g , peronance l , gastagna g , moro g , santi d , d'orazio a , et al. Immunohistochemical study of carcinoembryonic antigen (cea) in gastric tumors: correlation with preoperative serum levels, histologic type and grade of anaplasia of tumors. J surg oncol 1988;37:13-9. Crossref medline web of science ↵ hynes r. viagra no prescription Integrins: a family of cell surface receptors. viagra no prescription Cell 1987;48:549-54. Crossref medline web of science ↵ kaneko a , suzuki s , hara m , mori j , kumagai m , yajima h , et al. 1,25-dihydroxy vitamin d3 suppresses the expression of the vcam-1 receptor, vla-4 in human leukemic hl-60 cells. Biochem biophys res commun 1999;255:371-6. cheap viagra online Crossref medline web of science ↵ tomita y , saito t , saito k , oite t , shimizu f , sato s. Possible significance of vla-4 (alpha 4 beta 1 ) for hematogenous metastasis of renal-cell cancer. Int j cancer 1995;60:753-8. Medline web of science ↵ hynes r. Integrins: versatility, modulation and signaling in cell adhesion. Cwh 1992;69:11-25. generic viagra express shipping Search google s.        






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